A team of researchers affiliated with a host of institutions across Japan has found that inhibiting kidney-type glutaminase-dependent glutaminolysis in mice can lead to elimination of senescent cells. In their paper published in the journal Science, the group describes using RNA interference to look for enzymes that are required for senescent cell survival and subsequently inducing them to die. Christopher Pan and Jason Locasale, with the Duke University School of Medicine, have published a Perspectives piece in the same journal issue outlining research into glutamine and the role it played in the work done by the team in this new effort.
Cells are described as senescent when they lose the ability to divide. Prior research has found that cells can reach senescence due to exposure to stress, which can include mitochondrial, replicative or oxidative stress. In all cases, the cells live and continue to function, but can no longer divide. Prior research has found evidence suggesting that senescent cells play a role in the development of some aging-related diseases such as arteriosclerosis and muscle degeneration. For that reason, scientists have been looking for ways to eliminate them. In this new effort, the researchers have found a way to rid test mice of senescent cells by removing a pathway necessary for their continued survival.
The work involved a screening effort using RNA interference to look for enzymes that senescent cells need to survive. This led them to look closer at glutamine metabolism, specifically glutaminase 1. Testing showed it to be critical to survival for senescent cells. The team then inhibited the glutaminase 1 pathway in test mice. After allowing time for the changes to take effect, the researchers found that inhibiting the pathway led to the deaths of senescent cells. In the longer term, they found that it also reduced age-related organ problems and also health issues related to obesity.
The researchers suggest that inhibiting a similar enzyme in humans could likely promote senescent cell death as well, and by extension, reduce age-related disease.
The world’s first successful identification and characterization of in vivo senescent cells
Yoshikazu Johmura et al. Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders, Science (2021). DOI: 10.1126/science.abb5916
Christopher Pan et al. Targeting metabolism to influence aging, Science (2021). DOI: 10.1126/science.abf6368
© 2021 Science X Network
Inhibiting KGA-dependent glutaminolysis in mice found to eliminate senescent cells (2021, January 15)
retrieved 15 January 2021
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
- What to know about the side effects of the COVID-19 vaccination - March 2, 2021
- Underarm Lump After COVID Shot Is Likely Lymph Swelling, Not Breast Cancer, Experts Say - March 2, 2021
- फीस नहीं देने के कारण परीक्षा से नहीं किया जाएगा वंचित: राज्य मंत्री श्री परमार - March 2, 2021
- WHO expert panel strongly advises against use of hydroxychloroquine to prevent COVID-19 - March 2, 2021
- U.S. Flu Vaccinations Hit New Record High This Season - March 2, 2021
- कोरोना वैक्सीनेशन संबंधी जानकारी देने के लिए पांच अधिकारी नामांकित - March 2, 2021
- Why you still can’t visit unmasked, even if you’re fully vaccinated - March 2, 2021
- Vaccinating Oldest First for COVID Saves the Most Lives: Study - March 2, 2021
- पचोर नगर की जलावर्धन योजना के लिए भूमि आवंटित - March 2, 2021
- States easing virus restrictions despite experts’ warnings - March 2, 2021