In a study in mice and human cells, Johns Hopkins Medicine researchers say that they have developed a tiny, yet effective method for preventing premature birth. The vaginally-delivered treatment contains nanosized (billionth of a meter) particles of drugs that easily penetrate the vaginal wall to reach the uterine muscles and prevent them from contracting. If proven effective in humans, the treatment could be one of the only clinical options available to prevent preterm labor. The FDA has recommended removing Makena (17-hydroxyprogesterone caproate), the only approved medicine for this purpose, from the market.
The study was published Jan. 13 in Science Translational Medicine.
There are an estimated 15 million premature births each year, making it the number one cause of infant mortality worldwide. Few indicators can predict which pregnancies will result in a pre-term birth, but inflammation in the reproductive tract is a contributing factor in approximately one third of all cases. This symptom not only puts babies at risk of being born with low birth weights and underdeveloped lungs, but also has been linked to brain injuries in the developing fetus.
The newly reported experimental therapy uses technology developed by scientists at the Johns Hopkins Center for Nanomedicine. Its active ingredients are two drugs: progesterone, a hormone that regulates female reproduction, and trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor that regulates gene expression. To prepare the treatment, the drugs are first ground down into miniature crystals, about 200-300nanometers in diameter or smaller than a typical bacteria. Then, the nanocrystals are coated with a stabilizing compound that keeps them from getting caught in the body’s protective mucus layers that absorb and sweep away foreign particles.
“This means we can use far less drug to efficiently reach other parts of the female reproductive tract,” says Laura Ensign, Ph.D., associate professor of ophthalmology with a secondary appointment in gynecology and obstetrics at the Johns Hopkins University School of Medicine, co-author of the study, and an expert on nanomedicine and drug delivery systems.
To test their therapy, the researchers used mice that were engineered to mimic inflammation-related conditions that would lead to preterm labor in humans. They found that the experimental treatment prevented the mice from entering premature labor. Neurological tests of mouse pups born to mothers that had received the treatment revealed no abnormalities.
The researchers also applied the drug combination to human uterine cells grown in the lab. The drug combination, they report, decreased contractions in the test samples.
Additional laboratory tests of the experimental treatment are planned to evaluate its safety before considering trials in humans.
Researchers identify drugs that could halt preterm labor
Hannah C. Zierden et al, Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth,
Science Translational Medicine 13 Jan 2021: Vol. 13, Issue 576, eabc6245. stm.sciencemag.org/lookup/doi/ … scitranslmed.abc6245
Nanotechnology prevents premature birth in mouse studies (2021, January 13)
retrieved 13 January 2021
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
- होशंगाबाद जिला प्रशासन की बड़ी कार्रवाई - January 17, 2021
- Pfizer, BioNTech to limit delays of vaccine shipments to one week - January 17, 2021
- निर्वाचन आयोग ने फोटोयुक्त मतदाता सूची का अन्तिम प्रकाशन किया - January 17, 2021
- Serbia gets Chinese-made Sinopharm jabs - January 17, 2021
- सीवरेज परियोजनाओं का कार्य तीव्र गति से किया जाए - January 17, 2021
- Graft Versus Host Disease (GVHD): Symptoms, Treatment & Prognosis - January 17, 2021
- Study finds COVID isolation worsens student diets, inactivity, and alcohol intake - January 17, 2021
- रोजगारोन्मुखी योजनाओं से जोड़कर दिव्यांगजन को आत्मनिर्भर बनाएं - January 16, 2021
- India starts huge vaccine drive as global virus deaths top 2 million - January 16, 2021
- श्री सारंग ने वैक्सीन लगवाने वाले लोगों की हौसला अफजाई की - January 16, 2021