FRIDAY, Oct. 16, 2020 — An experimental drug combination lengthens survival for patients with amyotrophic lateral sclerosis (ALS), new research shows.
A previous clinical trial found that the two-drug combo — called AMX0035 — slowed progression of the neurodegenerative disease over six months.
The new clinical trial of 137 patients with the disease, also known as Lou Gehrig’s disease, found that those who took AMX0035 lived a median of 6.5 months longer than those who received a placebo. Median means half lived longer, half for less time.
The study, published Oct. 16 in the journal Muscle & Nerve, was conducted by researchers at Massachusetts General Hospital in Boston and Amylyx Pharmaceuticals, Inc., which makes the drug.
According to The New York Times, the drug combination was dreamed up by two Brown University students seven years ago. It combines an existing supplement and a medication for a pediatric urea disorder.
There is no cure for ALS, in which increasing damage to brain and nerve cells in the spinal cord results in a progressive loss of one’s ability to move, speak, eat and even breathe.
AMX0035 is designed to reduce the death and dysfunction of motor neurons, according to the new report.
Findings published last month in the New England Journal of Medicine reported that the drug slowed progression of ALS paralysis by about 25% more than a placebo, according to the Times.
The latest results “provide substantial evidence supporting the role of AMX0035 for the treatment of ALS,” said study leader Dr. Sabrina Paganoni, an investigator at the Healey and AMG Center for ALS at Mass General. “Next steps will depend on ongoing discussions with regulatory agencies,” she said in a hospital news release.
Senior author Dr. Merit Cudkowicz, director of the Center for ALS, described the study as groundbreaking.
“This is one of the first studies to show effect on both function and survival,” she said. “We are hopeful that this is just the beginning of many new treatments for ALS.”
Both researchers are on the faculty at Harvard Medical School. Paganoni is an assistant professor of physical medicine and rehabilitation and Cudkowicz is chief of neurology.
© 2020 HealthDay. All rights reserved.
Posted: October 2020
- How to make and distribute a vaccine - October 22, 2020
- Good Jane Announces 'Hot for Teachers CBD Deal' – One-Use $20 Discount for Teachers - October 22, 2020
- College Sports Fans Have a New Way to Mow with School Pride - October 22, 2020
- कोविड में तनाव से जूझ रहे बच्चों के लिए बाल आयोग ने शुरू की “संवेदना टोल फ्री टेली काउंसलिंग - October 22, 2020
- Health Tips If You Are Eating These Fruits Empty Stomach, You Are Doing It Wrong - October 22, 2020
- Gnosis Pharmaceuticals Pvt Ltd Urgent Requirement for Production manufacturing Packing QA PPIC Formulation and Development Apply Now - October 22, 2020
- Exercising one arm has twice the benefits - October 22, 2020
- GHS Holdings Announces Launch of First BlocAid™ Antibacterial Gloves - October 22, 2020
- Families Find Life Lessons in Raising Chickens - October 22, 2020
- वन विहार में 2 नवजात चौसिंगा आये - October 22, 2020