(HealthDay)—An increased risk for nonfatal drug-related poisoning is associated with benzodiazepine treatment in patients with opioid use disorder, according to a study published online March 3 in The American Journal of Psychiatry.
Kevin Y. Xu, M.D., from the Washington University School of Medicine in St. Louis, and colleagues used data from the IBM MarketScan database (2006 to 2016) to identify prescription claims in persons (aged 12 to 64 years) with opioid use disorder who were prescribed buprenorphine and who experienced drug-related poisoning.
The researchers found that buprenorphine treatment days were associated with a reduction in the risk for poisoning events (odds ratio [OR], 0.63) relative to nontreatment days. Benzodiazepine treatment days were associated with an increase in the risk for such events (OR, 1.88). There was an increase seen in poisonings associated with low-dose (OR, 1.78) and high-dose benzodiazepine treatment (OR, 2.22). High-dose benzodiazepine treatment was associated with increased poisonings in combination with buprenorphine cotreatment (OR, 1.64), but this was lower than the risk associated with benzodiazepine treatment in the absence of buprenorphine (ORs, 1.69 and 2.23 for low-dose and high-dose, respectively).
“Dose reduction of benzodiazepines while maintaining buprenorphine treatment may have the advantage of lowering drug-related poisoning risk,” the authors write.
Opioid overdose reduced in patients taking buprenorphine
Abstract/Full Text (subscription or payment may be required)
Copyright © 2021 HealthDay. All rights reserved.
Citation:
Benzodiazepines up risk for nonfatal drug-related poisoning in OUD (2021, April 2)
retrieved 3 April 2021
from https://medicalxpress.com/news/2021-04-benzodiazepines-nonfatal-drug-related-poisoning-oud.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
- Two distinct types of COVID-19-associated acute respiratory distress syndrome identified - April 15, 2021
- South India's First Laser Assisted Primary Angioplasty Saves Patient with Cardiac Shock at Kauvery Hospital, Chennai - April 15, 2021
- प्रदेश में प्रारंभ हुए 94 कोविड केयर सेंटर - April 15, 2021
- CBD or THC? Cannabis Product Labels Often Mislead, Study Finds - April 15, 2021
- Good dental health may help prevent heart infection from mouth bacteria - April 15, 2021
- फलदार पौधों को प्रदेश में ही नहीं देश में सप्लाई करती है पचमढ़ी की नर्सरियाँ - April 15, 2021
- A Woman’s Exposure to DDT Could Affect Her Granddaughter’s Health Today - April 15, 2021
- Open the windows to curb COVID spread: experts - April 15, 2021
- मुख्यमंत्री श्री चौहान ने मुख्यमंत्री निवास में मौलश्री का पौधा रोपा - April 15, 2021
- Links Between Gum Disease and Alzheimer’s - April 15, 2021
