Colyte (peg-3350 and electrolytes) Colonoscopy Prep Side Effects


Generic drug: peg-3350 and electrolytes

Brand name: Colyte

What is Colyte (peg-3350 and electrolytes), and how does it work?

Colyte (peg-3350 and electrolytes) is a prescription medicine used to clean the colon before a colonoscopy or barium enema X-ray examination. Colyte cleans your colon by causing you to have diarrhea. Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy or barium enema X-ray examination.

It is not known if Colyte is safe and effective in children.

What are the side effects of Colyte?

Colyte can cause serious side effects, including:

  • changes in certain blood tests. Your healthcare provider may do blood tests after you take Colyte to check your blood for changes. Tell your healthcare provider if you have any symptoms of too much fluid loss, including:
  • ulcers of the bowel or bowel problems (ischemic colitis). Tell your healthcare provider right away if you have severe stomach-area (abdomen) pain or rectal bleeding.

The most common side effects of Colyte include:

  • nausea
  • stomach-area (abdomen) fullness and bloating

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Colyte. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

One Gallon
For Gastrointestinal Lavage


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What drugs interact with Colyte?

Drugs That May Increase Risks Due to Fluid and Electrolyte Abnormalities

  • Use caution when prescribing Colyte for patients with conditions, or who are using medications, that increase the risk for fluid and electrolyte disturbances or may increase the risk of adverse events of seizures, arrhythmias, and prolonged QT in the setting of fluid and electrolyte abnormalities.
  • Consider additional patient evaluations as appropriate in patients taking these concomitant medications.

Potential for Altered Drug Absorption

  • Oral medication administered within one hour of the start of administration of Colyte may be flushed from the gastrointestinal tract and the medication may not be absorbed properly.

Is Colyte safe to use while pregnant or breastfeeding?

  • It is not known whether Colyte can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity.
  • Colyte should be given to a pregnant woman only if clearly needed. It is not known whether this drug is excreted in human milk.
  • Because many drugs are excreted in human milk, caution should be exercised when Colyte is administered to a nursing woman.

Medically Reviewed on 2/26/2021


All sections courtesy of the U.S. Food and Drug Administration

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