Epinephrine for Allergic Emergency: Side Effects & Warnings



What are the side effects of Adrenaclick?

Adrenaclick may cause serious side effects.

  • Adrenaclick should only be injected into the middle of your outer thigh (upper leg). Do not inject Adrenaclick into your:
    • veins
    • buttocks
    • fingers, toes, hands or feet

If you accidently inject Adrenaclick into any other part of your body, go to the nearest emergency room right away. Tell the healthcare provider where on your body you received the accidental injection.

  • Rarely, people who have used Adrenaclick may develop infections at the injection site within a few days of an injection. Some of these infections can be serious. Call your healthcare provider right away if you have any of the following at an injection site:
    • redness that does not go away
    • swelling
    • tenderness
    • the area feels warm to the touch
  • Cuts on the skin, bent needles, and needles that remain in the skin after the injection, have happened in young children who do not cooperate and kick or move during an injection. If you inject a young child with Adrenaclick, hold their leg firmly in place before and during the injection to prevent injuries. Ask your healthcare provider to show you how to properly hold the leg of a young child during an injection.
  • If you have certain medical conditions, or take certain medicines, your condition may get worse or you mayhave more or longer lasting side effects when you use Adrenaclick. Talk to your healthcare provider about all your medical conditions.

Common side effects of Adrenaclick include:

These side effects may go away with rest. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Adrenaclick. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Allergies can best be described as:
See Answer

What is the dosage for Adrenaclick?

Recommended Dosage According To Patient Body Weight

  • Patients greater than or equal to 30 kg (approximately 66 pounds or more): 0.3 mg
  • Patients 15 kg to 30 kg (33 pounds to 66 pounds): 0.15 mg

Administration Instructions

  • Inject the single-dose Adrenaclick intramuscularly or subcutaneously into the
    anterolateral aspect of the thigh, through clothing if necessary. Do not inject
    intravenously, and do not inject into buttocks, into digits, hands or feet.
  • Instruct caregivers of young children who are prescribed an Adrenaclick and who
    may be uncooperative and kick or move during an injection to hold the leg firmly
    in place and limit movement prior to and during an injection.
  • Each Adrenaclick is a single-dose of epinephrine injection for single use. Since the doses of epinephrine delivered from Adrenaclick are fixed, consider using other forms of injectable epinephrine if doses lower than 0.15 mg are deemed necessary.
  • With severe persistent anaphylaxis, repeat injections with an additional
    Adrenaclick may be necessary. More than two sequential doses of epinephrine
    should only be administered under direct medical supervision.
  • The epinephrine solution in the viewing window of Adrenaclick should be inspected visually for particulate matter and discoloration.

What drugs interact with Adrenaclick?

Cardiac Glycosides, Diuretics, And Anti-arrhythmics

  • Patients who
    receive epinephrine while concomitantly taking cardiac glycosides, diuretics, or
    anti-arrhythmics should be observed carefully for the development of cardiac

Antidepressants, Monoamine Oxidase Inhibitors, Levothyroxine, And Antihistamines

Beta-Adrenergic Blockers

  • The cardiostimulating and bronchodilating effects of epinephrine are antagonized by beta-adrenergic blocking drugs, such as propranolol.

Alpha-Adrenergic Blockers

  • The vasoconstricting and hypertensive effects of epinephrine are antagonized by alpha-adrenergic blocking drugs, such as phentolamine.

Ergot Alkaloids

  • Ergot alkaloids may also reverse the pressor effects of epinephrine.

Is Adrenaclick safe to use while pregnant or breastfeeding?

  • There are no available human data on the use of Adrenaclick in pregnant women to inform a drug-associated risk of adverse developmental outcomes.
  • Epinephrine is the first-line medication of choice for the treatment of anaphylaxis during pregnancy in humans.
  • Epinephrine should be used for treatment of anaphylaxis during pregnancy in the same manner as it is used in non-pregnant patients.
  • There are no data on the presence of epinephrine in human milk, or the effects of epinephrine on the breastfed infant or on milk production.
  • Epinephrine is the first line-medication of choice for treatment of anaphylaxis; it should be used in the same manner in breastfeeding and no-breastfeeding patients.


Could I Be Allergic? Discover Your Allergy Triggers
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Medically Reviewed on 4/7/2021


All sections courtesy of the U.S. Food and Drug Administration


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