Fluzone High-Dose (Influenza Vaccine): Side Effects & Warnings


Generic drug: Influenza Vaccine

Brand name: Fluzone Highdose

What is Fluzone High-Dose (Influenza Vaccine), and how does it work?

Fluzone High-Dose Quadrivalent is a vaccine that helps protect against influenza illness (flu).

Fluzone High-Dose Quadrivalent vaccine is for people 65 years of age and older.

Vaccination with Fluzone High-Dose Quadrivalent vaccine may not protect all people who receive the vaccine.

What are the side effects of Fluzone Highdose?

The most common side effects of Fluzone High-Dose Quadrivalent vaccine are:

These are not all of the possible side effects of Fluzone High-Dose Quadrivalent vaccine. You can ask your healthcare provider for a list of other side effects that is available to healthcare professionals.

Call your healthcare provider for advice about any side effects that concern you. You may report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967 or https://vaers.hhs.gov.

What is the dosage for Fluzone Highdose?

For intramuscular use only

Dose And Schedule

  • Fluzone High-Dose Quadrivalent should be administered as a single 0.7 mL injection by the intramuscular route in adults 65 years of age and older.


  • Inspect Fluzone High-Dose Quadrivalent visually for particulate matter and/or discoloration prior to administration. If either of these conditions exists the vaccine should not be administered.
  • Before administering a dose of vaccine, shake the prefilled syringe.
  • The preferred site for intramuscular injection is the deltoid muscle. The vaccine should not be injected into the gluteal area or areas where there may be a major nerve trunk.
  • Do not administer this product intravenously.
  • Fluzone High-Dose Quadrivalent should not be combined through reconstitution or mixed with any other vaccine.

Medically Reviewed on 2/25/2021


All sections courtesy of the U.S. Food and Drug Administration

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