Lung Cancer Drug Side Effects & Warnings

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Adverse Reactiona Dosage Modifications Central Nervous System Effects Grade 1 Continue at the same dose or withhold the dose until recovery to baseline. Resume
Lorbrena at the same dose or at a reduced dose. Grade 2 OR Grade 3 Withhold dose until Grade 0 or 1. Resume Lorbrena at a reduced dose. Grade 4 Permanently discontinue Lorbrena. Hyperlipidemia Grade 4 hypercholesterolemia OR Grade 4 hypertriglyceridemia Withhold Lorbrena until recovery of hypercholesterolemia and/or hypertriglyceridemia to less than or equal to Grade 2. Resume
Lorbrena at the same dose. If severe hypercholesterolemia and/or hypertriglyceridemia recurs, resume
Lorbrena at a reduced dose. Atrioventricular (AV) Block Second-degree AV block Withhold Lorbrena until PR interval is less than 200 ms. Resume
Lorbrena at a reduced dose. First occurrence of complete AV block Withhold Lorbrena until

  • pacemaker placed OR
  • PR interval less than 200 ms.

If a pacemaker is placed, resume Lorbrena at the same dose.
If no pacemaker is placed, resume Lorbrena at a reduced dose. Recurrent complete AV block Place pacemaker or permanently discontinue Lorbrena. Interstitial Lung Disease (ILD)/Pneumonitis Any Grade treatment-related ILD/Pneumoniti s Permanently discontinue Lorbrena. Hypertension Grade 3 (SBP greater than or equal to 160 mmHg or DBP greater than or equal to 100 mmHg; medical intervention indicated; more than one antihypertensive drug, or more intensive therapy than previously used indicated) Withhold Lorbrena until hypertension has recovered to Grade 1 or less (SBP less than 140 mmHg and DBP less than 90 mmHg), then resume
Lorbrena at the same dose. If Grade 3 hypertension recurs, withhold
Lorbrena until recovery to Grade 1 or less, and resume at a reduced dose. If adequate hypertension control cannot be achieved with optimal medical management, permanently discontinue
Lorbrena. Grade 4 (life-threatening consequences, urgent intervention indicated) Withhold Lorbrena until recovery to Grade 1 or less, and resume at a reduced dose or permanently discontinue
Lorbrena. If Grade 4 hypertension recurs, permanently discontinue
Lorbrena. Hyperglycemia Grade 3 ((greater than 250 mg/dL) despite optimal anti-hyperglycemic therapy OR Grade 4 Withhold Lorbrena until hyperglycemia is adequately controlled, then resume
Lorbrena at the next lower dosage. If adequate hyperglycemic control cannot be achieved with optimal medical management, permanently discontinue
Lorbrena. Other Adverse Reactions Grade 1 OR Grade 2 Continue Lorbrena at same dose or reduced dose. Grade 3 OR Grade 4 Withhold Lorbrena until symptoms resolve to less than or equal to Grade 2 or baseline. Resume
Lorbrena at reduced dose. Abbreviation: AV=atrioventricular; DBP=diastolic blood pressure; SBP=systolic blood pressure.
a Grade based on National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.03.



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