“Encouragingly, all these schedules generated antibody concentrations above that of the licensed and effective two dose Oxford-AstraZeneca schedule,” said Snape, Chief Investigator on the trial.
When it comes to cellular immunity, the researchers said, having a first dose of the AstraZeneca vaccine followed by any of the other study vaccines generates a particularly robust response.
In addition, a significantly higher number of short-lived vaccine reactions were reported in volunteers who received a second dose of Moderna compared to those who received two doses of either AstraZeneca or Pfizer.
“Using different types of vaccines within the same schedule as we have done here (for example mRNA vaccines, viral-vector vaccines or protein-based vaccines) is a relatively novel approach to immunisation,” Snape said.
“As well as providing evidence for flexibility in deployment, these results suggest this approach can also help generate better immune responses,” he added.
The researchers said the findings have implications beyond COVID-19 and will inform new approaches to immunisation against other diseases that are, as yet, not vaccine preventable.
- WHO counts 18 million virus cases last week as omicron slows - January 19, 2022
- Diet & Nutrition plan for a Head and Neck Cancer Patient - January 17, 2022
- COVID-19: HC urged to direct govt to give road map to vaccinate kids of 12 yrs and below - January 17, 2022
- 2,500 Delhi Police personnel infected, 767 cured of Covid since January 1 - January 17, 2022
- AstraZeneca vaccine trials show 3 doses give good protection against Omicron: Serum CEO - January 13, 2022
- Omicron Alert: FFD Launches Free Helpline For Diabetics - January 13, 2022
- Alkem Laboratories to Launch State of the Art Technology for Diabetic Foot Ulcer Management - January 13, 2022
- Metropolis Healthcare launches the 3rd edition of MedEngage Scholarship program to support aspiring young medical students - January 12, 2022
- Infections could surge 6 times higher due to omicron: Russia - January 12, 2022
- Makar Sankranti: Odisha bans religious gatherings; no holy dip at Haridwar - January 12, 2022