Mixing other vaccines with AstraZeneca, Pfizer jabs generates robust immune response: Lancet study

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“Encouragingly, all these schedules generated antibody concentrations above that of the licensed and effective two dose Oxford-AstraZeneca schedule,” said Snape, Chief Investigator on the trial.

When it comes to cellular immunity, the researchers said, having a first dose of the AstraZeneca vaccine followed by any of the other study vaccines generates a particularly robust response.

In addition, a significantly higher number of short-lived vaccine reactions were reported in volunteers who received a second dose of Moderna compared to those who received two doses of either AstraZeneca or Pfizer.

“Using different types of vaccines within the same schedule as we have done here (for example mRNA vaccines, viral-vector vaccines or protein-based vaccines) is a relatively novel approach to immunisation,” Snape said.

“As well as providing evidence for flexibility in deployment, these results suggest this approach can also help generate better immune responses,” he added.

The researchers said the findings have implications beyond COVID-19 and will inform new approaches to immunisation against other diseases that are, as yet, not vaccine preventable.

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