People living with the often-debilitating effects of Crohn’s disease may finally gain some relief, thanks to ground-breaking research led by McMaster University.
McMaster investigator Brian Coombes said his team identified a strain of adherent-invasive E-coli (AIEC) that is strongly implicated in the condition and is often found in the intestines of people with Crohn’s disease.
“If you examine the gut lining of patients with Crohn’s disease, you will find that around 70 to 80 percent of them test positive for AIEC bacteria, but one of the things we don’t understand is why,” said Coombes, professor and chair of the Department of Biochemistry and Biomedical Sciences, and the Canada Research Chair in Infectious Disease Pathogenesis.
“We believe that AIEC is a potential trigger of Crohn’s disease.”
By mutating every gene in a particular strain of AIEC and testing how those mutants grow in mice, the researchers were able to pinpoint which genes allowed the bacteria to freely colonize the gut linings of people with Crohn’s disease.
AIEC bacteria grow in a biofilm that coats cells lining the intestinal wall, protecting them from both the immune system and antibiotics. In this research, the team identified a critical protein structure on the surface of the bacteria that allow them to grow in biofilms.
Coombes said Crohn’s disease is caused by the immune system’s inability to “switch off” its inflammatory response to gut bacteria. Symptoms include severe diarrhoea, fatigue, weight loss and malnutrition.
Current treatments focus on easing the inflammation, but do not address the root cause of the condition.
“New therapies are on the way—we are one step closer to figuring out how this Crohn’s disease-associated bacteria lives in the gut and when we do that, we can develop new treatments,” said Coombes.
The team’s findings were led by postdoctoral fellow, Wael Elhenawy and published in Nature Communications.
Food-poisoning bacteria may be behind Crohn’s disease
Possible trigger for Crohn’s disease identified (2021, April 1)
retrieved 1 April 2021
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
- COVID Plus ‘Bleeding’ Stroke Doubles a Patient’s Death Risk - April 16, 2021
- खाद्य मंत्री श्री सिंह ने अनूपपुर में की कोरोना व्यवस्थाओं की समीक्षा - April 16, 2021
- Heavy energy drink consumption linked to heart failure in a young man - April 16, 2021
- AHA News: Waist Size May Better Predict AFib Risk in Men - April 16, 2021
- अब तक 69 लाख 69 हजार नागरिकों का हुआ वैक्सीनेशन - April 16, 2021
- Study reveals how some antibodies can broadly neutralize ebolaviruses - April 16, 2021
- ‘Magic Mushroom’ Hallucinogen as Good as Antidepressants: Study - April 16, 2021
- ऑक्सीजन टैंकर्स के लिये भी बनेगा ग्रीन कॉरीडोर, पायलेटिंग भी होगी - April 16, 2021
- Study estimates duration of employment loss experienced by adults with kidney failure - April 16, 2021
- JustLuxe Launches Yacht Showroom in Partnership with YATCO - April 16, 2021