Renal insufficiency may worsen multiple myeloma outcomes



Renal insufficiency may worsen multiple myeloma outcomes

(HealthDay)—For patients with multiple myeloma (MM), those with renal insufficiency (RI) have an increased risk for disease progression or death, according to a systematic review and meta-analysis published online Jan. 8 in Leukemia & Lymphoma.

Ghulam Rehman Mohyuddin, M.D., from the University of Kansas City in Kansas, and colleagues conducted a systematic review of all MM randomized clinical trials (RCTs) from 2005 to 2019 to examine reporting of prevalence, eligibility criteria, and outcomes of patients with RI and MM. Data were included for 123 RCTs.

The researchers found that 30 percent of the trials reported on the proportion of patients with RI and 68.2 percent reported eligibility criteria relating to RI; there was no uniformity in the reported criteria. Patients with versus those without RI had a significantly increased relative risk for disease progression or death (relative risks, 1.20 for relapsed/refractory MM and 1.07 for newly diagnosed MM).

“Patients with MM and RI enrolled [in] RCTs have inferior outcomes compared to patients without RI in both the relapsed/refractory and front-line setting,” the authors write. “There remains an urgent need for higher enrollment of patients with RI in RCTs and more consistent reporting of their enrollment criteria.”

Several authors disclosed financial ties to the pharmaceutical industry.

Triplet therapy slows refractory multiple myeloma

More information:
Abstract/Full Text (subscription or payment may be required)

Copyright © 2020 HealthDay. All rights reserved.

Renal insufficiency may worsen multiple myeloma outcomes (2021, January 22)
retrieved 23 January 2021

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.


Source link

Share and Enjoy !

0 0