THURSDAY, Jan. 14, 2021 — Biomarkers in sperm may help identify men at risk of fathering children with autism, researchers say.
For the study, investigators examined sperm epigenetics — the molecular processes that affect gene expression — in 13 men who fathered sons with autism and 13 who had children without the disorder.
The American and Spanish researchers focused specifically on DNA methylation, a chemical modification that can turn genes on or off.
“We can now potentially use this to assess whether a man is going to pass autism on to his children,” said study co-author Michael Skinner, professor of biological sciences at Washington State University, in Pullman, Wash.
“It is also a major step toward identifying what factors might promote autism,” he said in a university news release.
The study found 805 different DNA methylation regions that could be epigenetic biomarkers, indicating men more likely to have children with autism.
To test their findings about these biomarkers, the researchers used sperm samples from 18 men to see if they could identify those with and without children with autism. The results were 90% accurate, according to the study.
But Skinner and his colleagues said more research must be done before this approach can be used in clinical practice. The team is now working on a larger study involving 100 men.
“We found out years ago that environmental factors can alter the germline, the sperm or the egg, epigenetics,” Skinner said. “With this tool we could do larger population-based studies to see what kinds of environmental factors may induce these types of epigenetic changes.”
In 1975, autism was diagnosed in one in 5,000 people in the United States. As of 2020, one in 54 people in the United States has autism, according to the U.S. Centers for Disease Control and Prevention. Improved diagnosis and awareness account for some of that sharp increase, but many researchers believe that environmental and molecular factors have also played significant roles.
Previous research has shown that children can inherit the disorder from their parents, and that fathers are more likely than mothers to pass autism to their children, the study authors noted.
The report was published online Jan. 7 in the journal Clinical Epigenetics.
© 2021 HealthDay. All rights reserved.
Posted: January 2021
- COVID case rates hit new high for England, study finds - April 7, 2022
- Govt’s focus on affordable healthcare ensured significant savings for poor, middle class: PM Modi - April 7, 2022
- SRL Diagnostics and Skye Air Mobility collaborate to transport pathology samples using drone logistics - April 6, 2022
- Healthineers sets up new production line of CT scanners in Bengaluru under PLI scheme - April 6, 2022
- Lupin inks licensing pact with Alvion to market drugs in Southeast Asia - April 6, 2022
- Yoga Mahotsav: Ayush Ministry to organise event to demonstrate common yoga on World Health Day - April 6, 2022
- LordsMed forays into the medtech space with launch of health ATMs ‘Lords Sehat’ - April 5, 2022
- ‘Friendly viruses’ can be the next big thing in the history of medical research and more - April 5, 2022
- No setback to Bharat Biotech even as WHO suspends Covaxin UN supply: Sources - April 4, 2022
- Govt panel recommends Serum’s Covovax dose for kids aged 12 and above - April 4, 2022